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Systemic administration is a route of administration of medication, nutrition or other substance into the circulatory system so that the entire body is affected.cite-ref-1[1] Administration can take place via enteral administration (absorption of the drug through the gastrointestinal tract)cite-ref-2[2] or parenteral administration (generally injection, infusion, or implantation).cite-ref-3[3]cite-ref-mutschler-4-0[4]

Contrast with topical administration where the effect is generally local.cite-ref-mutschler-4-1[4]

cite-note-11. ↑ Hunnius Pharmazeutisches Wörterbuch (in German) (8th ed.). Berlin: Walter de Gruyter. 1998. p. 1477. ISBN 3-11-015793-4.

cite-note-22. ↑ "Enteral administration - pharmacology". britannica.com. Retrieved 19 April 2018.

cite-note-33. ↑ Hunnius Pharmazeutisches Wörterbuch (in German) (8th ed.). Berlin: Walter de Gruyter. 1998. pp. 472, 1029. ISBN 3-11-015793-4.

cite-note-mutschler-44. ↑ citerefmutschler2013Mutschler, Ernst (2013). Arzneimittelwirkungen (in German) (10 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 8. ISBN 978-3-8047-2898-1.